Grover’s Disease

What is Grover’s Disease?

Grover’s disease, also known as transient acantholytic dermatosis (TAD), is a common itchy rash that typically affects adult individuals and classically presents on the trunk, upper arms, and thighs.

Who is at risk for Grover’s Disease?

It may be more common in Caucasian individuals, especially in the fifth to seventh decades of life. Immunosuppression may increase the risk of developing Grover’s Disease, as it is seen in patients with HIV infection, leukemia, and in patients recently receiving bone marrow transplants. Sun damage and dry skin may also put patients at a higher risk. In addition, certain medications have been reported in association with Grover’s disease: anastrozole, vemurafenib, dabrafenib, cetuximab, mercury, D-penicillamine.

What causes Grover’s Disease?

The actual cause is unknown. Grover’s may be triggered by heat, sweating, and occlusion (tight clothes) and may persist for years. Patients can present after trips to tropical or semitropical climates with fever, and after hospitalization or bed rest.

What are the signs/symptoms of Grover’s Disease?

The characteristic lesion is a crusted red bump, pustule (pimple appearing), or a mix of the two that can be severely itchy on the trunk, upper arms, and/or thighs. These spots can persist for years, especially underneath the breasts.

How is Grover’s Disease diagnosed?

Grover’s disease is typically diagnosed clinically, but may require a skin biopsy.

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