What is Porphyria Cutanea Tarda?
Porphyria cutanea tarda (PCT) is a condition that manifests as skin fragility and blistering, often on sun-exposed areas like the hands and forearms. It is caused by a deficiency in a liver enzyme, uroporphyrinogen decarboxylase (UROD), which leads to the buildup of porphyrins.
Who is at risk?
People with a family history of PCT, those with acquired liver disease, and those who consume a lot of alcohol are at a higher risk. Other risk factors include Hepatitis B and C, iron overload, estrogen use, HIV, and smoking. Many patients have multiple risk factors.
What are the signs and symptoms?
PCT symptoms include fragile skin, blisters, erosions, scars, milia, and hyperpigmentation on sun-exposed areas including the face, neck, and feet. Additionally, women may experience excessive hair growth. Urine may appear reddish or tea-colored.